Illumina, a global company in DNA sequencing and array-based technologies, has launched its MiSeq i100 Series of sequencing systems. The new systems aim to advance next-generation sequencing (NGS) capabilities for laboratories, offering rapid turnaround and ease of use.
The MiSeq i100 and MiSeq i100 Plus systems provide labs with sequencing tools designed to be affordable and simple to use, even for those with limited NGS expertise. Both systems offer room-temperature storage and shipping, enabling labs to begin sequencing immediately without thawing reagents. According to Illumina’s CEO, Jacob Thaysen, “Our customers told us they need a faster, smaller, and easy-to-use instrument, and that’s what we’re delivering with the MiSeq i100.”
Building on the original MiSeq System launched in 2011, the MiSeq i100 incorporates technology from Illumina’s NovaSeq X Series. The systems offer two configurations: the MiSeq i100 Plus System, providing up to 100 million single-end reads per run, and the MiSeq i100 System, which offers a maximum of 25 million single-end reads per run.
One of the key features of the MiSeq i100 Series is its use of Illumina’s XLEAP-SBS chemistry, offering room-temperature reagent storage and shipping, which reduces the environmental impact and eliminates cold-chain requirements. Other features include reduced packaging waste, faster sequencing times, and simplified workflows for small whole-genome sequencing and targeted NGS panels.
Steve Barnard, Illumina’s Chief Technology Officer, noted that “the MiSeq i100 sets a new standard for benchtop sequencing,” highlighting its speed, scalability, and quality.
Early access testing with labs worldwide has provided positive feedback. Geneviève DonPierre from Génome Québec said, “With this new instrument, we are able to provide answers quickly for small projects or for researchers who need fast answers.” DonPierre also mentioned the convenience of room-temperature storage, eliminating the need to plan sequencing runs in advance.
Tim Roloff Handschin from the University of Zurich praised the flexibility of the MiSeq i100, “We can start two runs on the same day and increase our sample flow massively.” Handschin’s lab focuses on developing diagnostic tests and studying antimicrobial resistance.
Illumina revealed the MiSeq i100 during a virtual customer event. The system will be available for global shipping in 2025.
This article contains forward-looking statements. These are subject to risks and uncertainties, including challenges in product development and adoption, as detailed in Illumina’s filings with the Securities and Exchange Commission.