The company has joined hands with Griffith University by entering into agreement for research collaboration to conduct exploratory research to develop lead vaccine candidate for Coronavirus
Indian Immunologicals (II) has announced that the company is going to commence research for developing a vaccine for Corona Virus (COVID-19), the pandemic which has infected more than a million and killed about 55,000 people across the world so far. The Hyderabad, India, headquartered vaccine maker joined hands with Griffith University of Australia by entering into an agreement for research collaboration to conduct exploratory research to develop a lead vaccine candidate for Coronavirus.
In this significant cross-continental collaboration, scientists from Indian Immunologicals and Griffith University will develop a ‘Live Attenuated SARS – CoV-2 vaccine’ or COVID-19 vaccine using the latest codon de-optimisation technology. The technology looks promising for developing a vaccine for prophylactic, active, single dose immunisation against coronavirus in humans, with an enhanced safety profile. The vaccine is expected to provide long-lasting protection with a single dose administration with an anticipated safety profile similar to other licensed vaccines for active immunisation.
Upon completion of the research, the vaccine strain will be transferred to Indian Immunologicals and the vaccine maker will work accordingly with the country’s regulator – CDSCO (The Central Drugs Standard Control Organisation) – to further conduct clinical trials which will be taken up in a phased manner. II intends to use its existing Vero cell platform technology for mass production of the virus.
Speaking on the development, Dr K Anand Kumar, Managing Director, Indian Immunologicals said, “II is committed to addressing critical public health needs by engaging in this research collaboration. The mission at II is to develop and supply vaccines that support the One Health initiative. II has taken up this initiative to develop a vaccine candidate for the pandemic – COVID-19. II’s leadership in producing safe and affordable human and veterinary vaccines will enable us to progress well in this endeavour.”
Commenting on the research collaboration, Dr Prasanna Deshpande, Dy Managing Director, Indian Immunologicals said, “After evaluating various options being followed across the world, we decided to develop a Live Attenuated COVID-19 vaccine based on codon de-optimisation technology. With our dedicated research and development capabilities supported with excellent team of scientists and engineers, IIL is committed to developing high-quality vaccines that are affordable. We are confident that this new cross-continental collaboration will yield the desired results.”
“We are very excited to be able to work closely with Indian Immunological for development of this important vaccine to solve this urgent public health crisis. Our live-attenuated vaccine will be developed using codon de-optimisation technology and is expected to provide long lasting immunity against SARS – CoV-2 following a single immunisation and cross-protection against other coronaviruses (e.g. MERS, SARS-CoV-1). As this vaccine will be a live attenuated vaccine it is expected to be highly effective by providing very strong cellular and antibody immune responses against the virus. The other benefit of a live-attenuated vaccine is a proven track record for economical large-scale manufacturing and well-known regulatory approval pathway,” said Professor Suresh Mahalingam, Menzies Health Institute Queensland, Griffith University, Australia on the research collaboration.
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