MultiOmic Health partners with QUB to develop data-driven diagnostic tools for DKD

MultiOmic and QUB will draw on their collective expertise to explore molecular-level similarities and differences in kidney disease amongst patients with type 1 and type 2 diabetes

MultiOmic Health, an Artificial Intelligence (AI) enabled drug discovery company, is embarking on a collaborative project with the Centre for Public Health at Queen’s University Belfast (QUB) in Northern Ireland to develop data-driven diagnostic tools for Diabetic Kidney Disease (DKD).

The two-year project is partially funded by a grant recently awarded to MultiOmic Health under Innovate UK’s £20 million Advancing Precision Medicine programme, supporting industry-led research projects to enable more accurate diagnosis and treatment stratification within the UK National Health Service (NHS).

MultiOmic will deploy its MOHSAIC platform to analyse data generated from de-identified samples collected previously as part of the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA) and the Finnish Diabetic Nephropathy Study (FinnDiane). The project seeks to tailor DKD treatment based on patients’ underlying characteristics, leading to improved health outcomes for patients.

MultiOmic and QUB will draw on their collective expertise to explore molecular-level similarities and differences in kidney disease amongst patients with type 1 and type 2 diabetes. The aim of the project, which began in December 2023, is to identify diagnostic and prognostic biomarkers for diabetic kidney disease progression and likely complications within specific patient subpopulations.

MultiOmic’s data-driven approach aims to overcome these limitations, offering a way to advance personalised approaches for DKD management.

“Previous studies in diabetic kidney disease lacked molecular-level comparisons using the multiple omics modalities that are needed to understand the combined impact of genetic, environmental and lifestyle factors,” explained Robert Thong, CEO, MultiOmic Health.

“Through this approach, we aim to deepen our understanding of the factors contributing to the onset and progression of this disease across the diabetes population. This first-of-its-kind study has the potential to revolutionise how we approach and treat diabetic kidney disease.”

“Our collaboration utilises resources from the NICOLA study, which was initiated in 2014 to investigate ageing and lifestyle impact on health outcomes,” said Bernadette McGuinness, Clinical Professor of Ageing at QUB and Principal Investigator of the NICOLA study.

“With over 8,500 participants from Northern Ireland aged 50 and above, the study provides a robust baseline to leverage further research. Combining QUB’s phenotype and molecular expertise with MultiOmic’s computational analysis capabilities, we are excited to use this opportunity to generate multi-modal omics data for a specific sub-cohort to uncover new insights in DKD.”

“Since 1997, the Finnish Diabetic Nephropathy Study (FinnDiane) has become a pivotal resource in diabetes research, playing a key role in uncovering the risk factors and mechanisms of diabetic complications in patients with type 1 diabetes,” said Niina Sandholm, co-Principal Investigator of the study group.

“Now, in this project, we are eager to explore the molecular parallels of kidney disease between type 1 and type 2 diabetes, helping to push forward strategies in diabetes prevention and treatment.”

The outcomes of this project will lay the groundwork for future diagnostic tools, providing clinicians with valuable insights into disease progression, complication risks, and drug responsiveness. This patient-centric approach to DKD management promises to optimise healthcare resource allocation, reduce disease progression, and enhance the overall quality of life for individuals with DKD.